Hypofractionated short-course preoperative conformal radiotherapy versus long course conventional preoperative chemoradiotherapy in the management of locally advanced rectal cancer – Prospective randomized comparative study
نویسندگان
چکیده
منابع مشابه
Preoperative short- vs. long-course chemoradiotherapy with delayed surgery for locally advanced rectal cancer
PURPOSE To compare the clinical outcomes between short-course chemoradiotherapy (CRT) and long-course CRT with delayed surgery in locally advanced rectal cancer patients. RESULTS From 2010 to 2015, 19 patients were treated with short-course CRT and 53 patients were treated with LCRT. The sphincter-saving rate (89.5% vs. 94.3%, short-course CRT vs. long-course CRT), pathologic complete remissi...
متن کاملSimultaneous integrated boost intensity-modulated radiotherapy versus 3-dimensional conformal radiotherapy in preoperative concurrent chemoradiotherapy for locally advanced rectal cancer
PURPOSE To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively...
متن کاملShort-versus Long-course Preoperative Radiotherapy plus Delayed Surgery for Rectal Cancer: a Meta-analysis
Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared...
متن کاملLong-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer.
BACKGROUND Neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short-course radiotherapy alone in patients with clinical stage T3 or T4 resectable rectal cancer. The aim of this study was to compare survival, local control and late toxicity in the two treatment groups. METHODS The study randomized 312 patients to receive either...
متن کاملPreoperative Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer
PURPOSE To evaluate the treatment tolerance and clinical outcomes in patients aged 70 and older with locally advanced rectal carcinoma treated with multimodality approach. METHODS AND MATERIALS We retrospectively analysed 20 consecutive elderly patients, with histologically proven rectal adenocarcinoma, staged T3-4, and/or node-positive tumour, who received chemoradiotherapy and proceeded to ...
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ژورنال
عنوان ژورنال: Panacea Journal of Medical Sciences
سال: 2020
ISSN: 2249-8176,2348-7682
DOI: 10.18231/j.pjms.2020.049